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Table 1 Characteristics of Medicare beneficiaries initiating antihypertensive monotherapy between 2008 and 2011 (n = 122,629)

From: Initiation of antihypertensive monotherapy and incident fractures among Medicare beneficiaries

 

ACE

n = 40,186

ARB

n = 10,954

BB

n = 36,972

CCB

n = 18,411

THZ

n = 16,106

Cohort

Cohort

SMRW

Cohort

SMRW

Cohort

SMRW

Cohort

SMRW

Mean Age, std. (years)

74, 6.7

75, 6.7

74, 12.9

75, 7.0

74, 7.1

76, 7.4

75, 10.0

75, 7.0

75, 10.8

Mean Frailty Index, std

0.1, 0.1

0.1, 0.1

0.1, 0.2

0.1, 0.1

0.1, 0.1

0.1, 0.2

0.1, 0.2

0.1, 0.1

0.1, 0.2

Male

42.0

36.6

41.5

41.7

42.2

37.8

42.1

29.3

42.4

White Race

87.1

79.0

87.3

88.8

86.9

81.8

86.9

86.5

87.2

Low-Income Subsidy

5.3

5.5

5.5

4.6

5.4

5.8

5.4

5.0

5.2

1–2 Meds Filleda

61.3

62.4

61.8

58.6

61.4

59.8

62.5

66.9

62.5

3–4 Meds Filleda

27.7

26.5

27.4

28.7

27.2

27.1

26.3

24.7

26.5

5 + Meds Filleda

11.1

11.2

10.8

12.7

11.4

13.0

11.3

8.5

11.1

Loop Diuretic

5.8

5.9

5.9

7.0

6.1

6.4

6.0

3.7

6.4

Antiarrhythmic

2.6

4.2

2.5

5.4

2.8

4.5

2.7

2.7

3.0

Antidepressantb

15.2

14.9

15.2

16.0

15.6

15.9

15.6

15.4

15.5

Antipilepticb

7.4

7.3

7.3

8.0

7.5

8.2

7.6

7.7

7.4

Anxiolytic

3.4

3.4

3.5

4.0

3.6

4.1

3.6

3.7

3.5

Benzodiazpeneb

1.1

1.0

1.1

1.4

1.2

1.3

1.2

1.3

1.1

Bisphosphonate

10.6

12.4

10.6

11.2

10.4

11.6

10.7

13.0

10.8

Antipsychoticb

3.5

2.8

3.5

4.2

3.7

4.9

3.7

3.8

3.7

Skeletal Muscle Relaxantb

6.2

6.2

6.2

6.5

6.5

6.3

6.4

6.5

6.4

Opioid

27.0

26.2

27.4

30.2

27.2

29.5

27.5

28.0

28.2

Hypnoticb

6.1

7.9

6.0

7.5

6.1

7.1

6.2

6.7

6.2

Diabetes

31.6

30.6

31.0

19.0

32.8

18.3

31.4

13.5

32.9

Chronic Kidney Disease

8.7

10.5

8.8

10.6

9.4

13.1

9.3

6.3

9.8

Parkinson’s Disease

1.2

1.1

1.2

1.5

1.2

1.5

1.2

1.3

1.2

Alzheimer’s Disease

3.2

2.4

3.1

3.0

3.4

4.4

3.3

3.1

3.6

Osteoporosis

14.1

17.3

14.2

16.0

14.1

17.4

14.4

16.9

14.6

Arrhythmia

10.5

10.9

10.4

32.9

10.6

25.4

10.6

8.5

11.6

Osteoarthritis

14.4

17.8

14.3

16.1

14.7

15.5

14.9

15.7

15.1

Rheumatoid Arthritis

2.5

3.4

2.5

3.2

2.6

3.0

2.7

2.5

2.6

Stroke

13.7

13.5

13.5

16.6

15.0

16.4

15.1

10.3

14.9

Myocardial Infarction

0.6

0.2

0.6

4.0

0.6

0.6

0.7

0.1

0.7

Hypertension

83.3

88.2

83.5

63.3

84.3

78.6

85.3

76.8

85.0

Orthostatic Hypotension

0.6

0.6

0.7

1.1

0.7

0.9

0.8

0.5

0.6

Syncope

3.8

4.2

3.7

7.4

4.0

6.1

4.2

3.0

4.3

Dementia

5.8

4.2

5.6

5.9

6.1

8.2

6.1

5.6

6.1

Urinary Incontinence

4.7

4.8

4.7

4.9

4.8

5.5

4.9

4.5

4.9

Dyslipidemia

64.8

70.2

64.2

64.0

65.7

58.2

65.3

57.2

65.3

Obesity

4.4

4.2

4.5

3.6

4.6

3.3

4.4

4.1

4.4

Home Oxygen Use

2.4

2.5

2.4

2.5

2.6

5.3

2.3

2.7

2.6

Walker/Wheelchair Use

2.2

2.4

2.2

2.8

2.3

3.3

2.3

2.4

2.5

Hospital Bed Use

0.5

0.5

0.5

0.5

0.5

0.9

0.5

0.5

0.6

Difficulty Walking

7.7

7.5

7.6

8.8

8.2

9.5

8.4

8.2

8.3

Vertigo

11.5

12.4

11.3

14.5

12.1

14.1

12.4

12.4

12.1

Ambulance Transport

6.9

4.7

6.8

12.4

7.3

12.5

7.3

5.4

7.5

Cancer Screenings

41.0

39.2

40.9

39.3

40.4

35.5

40.6

43.6

40.1

Hospital Admissions

13.2

10.1

13.2

25.5

13.6

23.8

13.4

10.0

14.3

  1. aNumber of number of distinct drug prescriptions filled in the 14 days prior to antihypertensive initiation
  2. bMedication indicated to be associated with fracture risk according to the 2015 Beers Medication Guideline (By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel 2015)
  3. Prevalence of baseline characteristics was identified 12 months prior to initiation of antihypertensive monotherapy
  4. Race was missing for a total of 147 beneficiaries and these were excluded from the SMR weighted analysis
  5. Standardized mortality ratio weighting (SMRW) was used to weight beneficiaries of each drug class to achieve the same baseline covariate distribution as beneficiaries receiving an ACE. Beneficiaries initiating with ACEs were assigned a weight of 1 and all others were assigned a weight that was the ratio of the propensity score to 1 minus the propensity score
  6. ACE Angiotensin converting enzyme inhibitors, ARB angiotensin receptor blockers, BB beta blockers, CCB calcium channel blockers, or THZ thiazide diuretics