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Table 2 Rates and hazard ratios of incident fractures within the first year of initiating antihypertensive monotherapy

From: Initiation of antihypertensive monotherapy and incident fractures among Medicare beneficiaries

Drug Class

1–14 days after initiation

15–365 days after initiation

# Fractures

P-Yrs

Rate Per 10,000 P-Yrs (95% CI)

SMRW HR (95% CI)

# Fractures

P-Yrs

Rate Per 10,000 P-Yrs (95% CI)

SMRW HR (95% CI)

ACE

54

1539

351 (266, 454)

ref

1271

36,618

347 (328, 367)

ref

ARB

14

420

333 (190, 546)

0.92 (0.49, 1.75)

322

10,032

321 (287, 358)

0.96 (0.84, 1.09)

BB

58

1416

410 (314, 526)

1.00 (0.65, 1.54)

1375

33,449

411 (390, 433)

1.09 (1.00, 1.19)

CCB

27

705

383 (258, 550)

0.82 (0.50, 1.36)

720

16,540

435 (404, 468)

1.11 (1.00, 1.24)

THZ

27

617

438 (294, 628)

1.40 (0.78, 2.52)

562

14,656

384 (353, 416)

1.02 (0.90, 1.15)

  1. P-Yrs person-years (calculated by dividing the total number of follow-up days by 365.25)
  2. SMRW Standardized mortality ratio weight, calculated adjusting for all baseline covariates
  3. Incident fracture rates and corresponding 95% CIs were defined as the total number of incident fractures by the total P-Yrs at risk. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using SMR weighted Cox proportional hazard models using a ‘first-treatment-carried-forward’ analysis design. CIs were calculated using robust standard errors to account for the SMRWs
  4. ACE Angiotensin converting enzyme inhibitors, ARB angiotensin receptor blockers, BB beta blockers, CCB calcium channel blockers, or THZ thiazide diuretics
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Injury Epidemiology

ISSN: 2197-1714