Drug Class
|
Probable Low Bone Mineral Density Fractures
|
Normal Bone Mineral Density Fractures
|
---|
# Fractures
|
P-Yrs
|
Rate Per 10,000 P-Yrs (95% CI)
|
SMRW HR (95% CI)
|
# Fractures
|
P-Yrs
|
Rate Per 10,000 P-Yrs (95% CI)
|
SMRW HR (95% CI)
|
---|
ACE
|
424
|
38,157
|
111 (101, 122)
|
ref
|
901
|
38,157
|
236 (221, 252)
|
ref
|
ARB
|
99
|
10,452
|
95 (77, 115)
|
0.93 (0.74, 1.17)
|
237
|
10,452
|
227 (199, 257)
|
0.97 (0.84, 1.13)
|
BB
|
464
|
34,864
|
133 (121, 146)
|
1.08 (0.93, 1.26)
|
969
|
34,864
|
278 (261, 296)
|
1.09 (0.98, 1.21)
|
CCB
|
280
|
17,245
|
162 (144, 182)
|
1.13 (0.95, 1.35)
|
467
|
17,245
|
271 (274, 296)
|
1.09 (0.96, 1.24)
|
THZ
|
171
|
15,273
|
112 (96, 130)
|
0.85 (0.68, 1.06)
|
418
|
15,273
|
274 (248, 301)
|
1.12 (0.98, 1.29)
|
-
P-Yrs person-years (calculated by dividing the total number of follow-up days by 365.25)
-
SMRW Standardized mortality ratio weight, calculated adjusting for all baseline covariates
- Incident fracture rates and corresponding 95% CIs were defined as the total number of incident fractures by the total P-Yrs at risk. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using SMR weighted Cox proportional hazard models using a ‘first-treatment-carried-forward’ analysis design. CIs were calculated using robust standard errors to account for the SMRWs”
- Probable low bone mineral density fractures included hip and radius fractures. All other non-vertebral fractures were defined as normal bone mineral density fractures
-
ACE Angiotensin converting enzyme inhibitors, ARB angiotensin receptor blockers, BB beta blockers, CCB calcium channel blockers, or THZ thiazide diuretics